Defence+ Gone Mad after update

My system has just updated its self and now Defence+ for the last 45 mins has just popped up one after another with message boxes for Run32.dll wants to run blah blah.
Before the update I did not get one. I am/was running in Safe mode - so I can use my machine I have had to disable defense+. :-TD
For example:
The system has checked every file that Run32.dll has wanted to run from Adobe reader and Lightroom.

I am running Windows 7 64bit.

This topic shines a light: https://forums.comodo.com/defense_help/rundll32dll_active_when_system_idle-t41620.0.html . The big amount of alerts may be related to the Application Experience.

When you opted in upon on installation of Win 7 to send data about usage to Microsoft then that is most likely the cause.