I realize this topic has been started elsewhere but I thought my issue might be helpful to the developers of CIS.
What happened was, the program was downloading the daily updates and it seemed to stall on the " downloading recognizers" . After a ½ hour I quit the program
and restated the machine. The task bar icon never came on and eventually the message that is the subject ABOVE was displayed. I rebooted several times but no luck
in clearing the error. In task manager, both cis and cmdagent were running, but no task bar icon and status shield that is displayed in the upper right hand corner
I ended up uninstalling the program and I want to thank Comodo for at least making the uninstall routine clean and thorough.