DLL (hook) blocking is a defense+ issue. You can verify them under
CIS-Defense±Advanced-Computer Security Policy
This portion lists the executables that are given access to run in your computer. If you face problems in any particular application or if you are aware that you have blocked a hook pertaining to a particular application
double click on the application - Click Access Rights
Click ‘Modify’ button - Blocked Applications
See whether there is any entry there. If you are sure of the application, you are remove the entry therein.
(Most of the programs, which are ‘safe’ as per Comodo, are given direct ‘Allow’ rule. Hence, for most of the programs you may not find any entry in those, except those where you have given an ‘Allow’ or ‘Block’ rule.)