I did a clean install of windows 10 today & reinstalled CIS. Upon its first restart, HIPS blocked cis.exe (Comodo main executable file). I unblocked it & then it got blocked again. I marked it as an allowed app through setting but it reverted back to custom setting. ???
Check the HIPS event logs to see what it was blocked from doing and check your HIPS rules as it sounds like the default rules are missing.