Is it ok to delete this folder in the All Users\Application Data folder? I don’t know if comodo uses the executable files in this folder for uninstallation also or only for installation.
You may want to consider to keep the installer for CIS in case you want to do a clean install of CIS. That way you don’t have to download it again. When doing a clean install CIS will download the AV database its self.
You can move the installer to another folder if you like. It is not needed when uninstalling.