I was reading the help files of CIS 5.0, and reference was made that CIS Sandbox is not as isolating as the sandbox created by the program Sandboxie.
My question is would it make sense to supplement CIS 5.0 with Sandboxie, or would the two programs conflict with one another.
No conflict between the two.
They can supplement each other depending on what you use sandboxie for.
You should be alright like that.
I use Sandboxie to sandbox my browser and email program.
Only use CIS sandbox as part of Defense+ for protection from unknown process only.