Instead of going through the process of Turing off all three and and clicking on the the pops up to permanently disable CIS is there away to turn it off with one click.
No it is not possible to disable all components with a single on/off switch, but a wish for this is in the tracker and listed here: https://forums.comodo.com/verified-wish-reports-cis/add-option-to-disable-all-protection-modules-with-a-single-click-m1280-t105279.0.html so it may or may not be implemented in the next CIS release.
I voted for the one click.
If you right click on the tray icon, you have then option to exit.
But, why would you want to shut all three modules of CIS down anyhow?