Auto-sandboxed software generates alerts (4.0.135239.724 x32)

I got hook alerts since early betas when documentation was not yet available.

COM alerts were were occasionally displayed since early betas.

AFAIK the com alert whose picture you attached would correspond to some V3 Interprocess Memory alerts (perhaps are triggered when some additional condition apply).

Whereas COM alerts could not be triggered sometimes the design decision was unclear but Hooks were predictably able to trigger alerts (or predictably fail in a specific case).