I am running version 6.3.294583.2397 after an update and restart yesterday 09-29-2013. When I click on the Comodo shortcuts on my desktop i get the “application not found” message for all of them. Only way I can access the internet is through Explorer. Any help? 
I will move this to the HELP section of the forum, as it is there where you have the greatest chances of finding someone who can advise you about this.
To me this sounds like something, or whatever reason, went very wrong with the install. It is likely fixable by reinstalling by following the advice I give in this topic. Be sure to follow my instructions carefully, including running the Comodo removal tools in Safe Mode.
Let me know how that goes.
Thank you.