All Malware Cannot be Removed?

Have you guys noticed this? I tested CIS on real system i.e no VM but with sandboxie. I noticed that CIS 5.8 for few malware gave popups all malware cannot be removed. Do you want a help from the techinician. I know this popup but never got this popup testing CIS. 5.8 gave this popup quite a few times.

I dont know this was coz I was testing with sandboxie? But one thing testing with sandboxie, Comodo autosandbox was not working, why?

Thanxx
Naren

Mixing Sandboxie with Comodo Sandbox is something to this effect while expecting them to work together