In some instances I find Comodo asking my permission for programs that I didn’t want running in the first place. I think it would be nice to have an option of outright killing the process (Or the process tree, which might get funky) accompanied by a checkbox to add the program to the blacklist. As it is now, I have to load up Task Manager, kill the process, then I have to wade through the multitude of Comodo prompts (Unless I treat it as an isolated app, which certainly speeds things up). Also having the blacklist option on the prompts would allow you to block programs as they come along without having to manually define each one.
The only drawback I can see is some lesser-knowledgeable people blacklisting explorer.exe or winlogon.exe, causing their PCs to essentially become crippled and unusable. Might be able to have it as an initially disabled option hidden behind a disclaimer if that really becomes a worry.