This is me on Windows XP Pro 32-bit SP3 with all current updates.
Was running CIS just fine until this afternoon when it reported that an update was available. I approved the update, and the updater crashed in the middle of its task, bringing up the bug report box. Telling it to send the report caused CIS to attempt to run Thunderbird [my default email client] which then also crashed. Locked hard with no choice but to hard reset.
Windows would crash hard upon rebooting and logging in.
The only way around this was to reboot in safe mode and completely remove CIS, which I did.
I then downloaded the newest CIS installer [dated 2009-11-17 which I assume means it includes the 11-17 updates] and re-installed.
Upon rebooting, the same issue persisted - hard lockup crash, no way out but hard reset. Only choice to continue using the machine was to remove CIS completely from safe mode again.