Hello LM,
I have tried what you proposed: uninstall all Comodo programs in safe mode with reboots in between, run CCleaner, install the Comodo programs in safe mode with reboots in between. Unfortunately in the end after normal startup, the san communication still has problems. So I finally decided to uninstall the Comodo firewall and revert to the Windows firewall for the time being (I know I have to find a better one).
Before I tried the Comodo firewall I had already tried a few others like Kaspersky, Bitdefender, ZoneAlarm, AVG. And I must say that AVG was the only one that did not interfere with the san communication. But before I decide to buy it I thought to give the free Comodo firewall a try. It is a pitty that it does not work (yet) for my network configuration.
The problem is that without the san driver it works well but then I cannot try to find a solution. And with the san driver I have the crashes, hang-ups and loss of san mirrorring (the driver sends data to both hard disks in the drive for that purpose). Restoring mirrorring each time costs me too much time.
I suspect the real reason to be related to that mirrorring (sending multiple messages or broadcasting or whatever way it is implemented).
Thank you for your help. I will monitor this thread to see if anyone comes up with more ideas/settings. Then I might give it a retry.