I have several portable apps too!!
This is what happens with me and this is what I do everytime. I have av on, hips safe mode, viruscope on, sandbox enabled
I put portable app to desktop.
I open portable app folder.
I click on .exe file.
Sandbox pops up, showing green border
On bottom right screen, I click on not to sandbox again
Then I close the sandbox program
Click on "reset sandbox"
Then click on portable .exe file again
This time the sandbox shouldnt sandbox the portable app
Also if you open up a couple of portable apps, run a AV scan (RATING SCAN) specifically. then click from unknown for the portable to "trusted"