Interesting, thank you both for the answers, I wasn't aware of that. (In Vivaldi it has something to do with streaming/multimedia, I believe.)
I don't use DNS over https yet, though (that setting is unchecked). I have to check whether OpenDNS supports it this way.
EDIT: Turns out OpenDNS supports it via doh.opendns.com. A more generic related question: If I set this to on, is the etc/hosts file observed by the browser (so, checking hosts first, DoH later)? I have some blacklist there.