As a test, I downloaded and ran a rogue to see just how effective CIS v4 really was. Everything was set to default.
Upon execution, I was greeted with two D+ alerts, and I chose Block for both. A sandbox alert then popped up saying the rogue was placed in a sandbox, for which I clicked OK. The rogue was running in front of me, but the sandbox led me to believe that my system was safe. But I was wrong.
I used Comodo to end the rogue's process, and while everything seemed fine, I wasn't convinced. To see if it touched the startup settings, I went to run an msconfig. Didn't work. I tried running another exe. It said it couldn't find a program to run the exe.
I restarted, hoping it would all be fixed on a restart. Nope. Nothing started on startup, and I couldn't even manually run Comodo. Now I have to reinstall Windows again. Joy. Luckily this is a fairly fresh install.
So, in conclusion: the new version of Comodo is far from bulletproof. Even with me, the user, clicking block on all the popups, the rogue was able to pass right through the sandbox.