Hi Rolo,
Well, … without reading all of it despite I read some of the links you pointed to I am quite surprised that it's called a
“phenomenon” 
1st, as it was pointed many many times – you cannot possibly rely on VirustTotal or any other online scanning submissions.
The reasons were already expressed I may not repeat that.
Then, currently on the market there are 3 major engines used by any existing AV solutions.
Most of them are Kaspersky and Avira engines.
There are several already, that are using double engine from a-squared (the recent example is Ashampoo)
The latter market is growing due to the best detection rate by a-squared that has a stable ranging in this area for a long long time.
Plus, as recent removal test and awards are showing a-squared is considered very strong in cleaning and the new version will bring more to that in addition to other innovations.
*** A side note:sure and there should not be any doubts that the AV or Ant-Malware that can clean “all” and correctly will ever be created
*** End of a side noteFinally re: engines
Probably Comodo has its own engine – I am not aware of that.
I tested the AV in the past & I'm not going to use it.
============
But then, and most important comment I would like to add (probably that is not very appropriate in the security related forum... but anyway
Did you ever tested keygens & cracks that are flagged by many security?

Do you know the percentage of those “detections" that are just fake?
How that is different to the main alleged
“discovery” by Kaspersky?
So, what many vendors are doing is: going “there – you know where”

; gathering “stuff” and creating signatures
Yes, yes... some of them are FPs because of packers ... but do you think the flagging will be fixed as soon as the packer cracked?
That is a fake & damaging way for whole industry to fight piracy – you have hundreds of thousands signatures that should not be there in the 1st place with all bad implications.
The
“phenomenon”

…
Kaspersky should look into their own problems first, rather than creating "tabloid style sensational news"
I'm not impressed at all - and ignoring that.
*** edited *** Sorry , I have to stress - I am ignoring Kaspersky , but not your message

Cheers!