Maybe it IS working, at least cleaning the list of trusted files made it ask again what to do with some applications unknown to it.
Otherwise I think that it is funny that it does not recognize so popular application as Pop Peeper.
It does recognise Pop Peeper here and now. May be that happened when the cloud had some look up problems. Does it get recognised right now?
Now I am trying to pinpointthis problem to AItoboforms taskicon service. I saw thet when launching malware files the Defence+ log shows that it is accessing the memory.
Now I have disabled the AIr oboforms Windows application integration, so that this service does not run.
When D+ is monitoring that it is blocking memory access then it is up and running. What are the problems that are happening right now? Did you try to import a factory default configuration profile as I suggested in the above to see if there is a problem with your configuration?