There are a couple things to understand about the Network rules (in v3, Firewall / Advanced / Global Security Policy / Global Rules)...
1. They filter from the top down. So if you have a rule to Allow below a rule that would Block, the Allow rule won't do anything.
2. p2p apps take some specific rules in order to be able to work, as you have to Allow unsolicited Inbound access on certain ports.
3. In order to communicate across a network, you have to create a Zone to define that, and rules to allow that communication.
Please refer to the FAQ; most (if not all) of your questions should be answered there...
https://forums.comodo.com/frequently_asked_questions_faq_for_comodo_firewall-b32.0/ Some are written for v2.x, rather than v3; while some details & wording may change, the concepts are still the same.
LM