I am wondering why folks who have tried NoScript would choose Comodo Dragon instead.
Maybe because they don't like NoScript?
You mention the usability of Firefox with NoScript, but I've always felt NoScript to be a hindrance. Not to mention I have trouble trusting it after the developer purposefully interfered with the operation of another extension. He effectively patched in a blind spot with a NoScript update. It was quickly discovered though, because it completely broke the other extension, instead of just the intended blind spot. NoScript is a self proclaimed security
extension, whose author isn't above malicious tampering of other peoples code...
I personally feel that using AdBlock Plus with a filter to block third party scripts is a much better option than NoScript. Locally hosted scripts really aren't a problem unless you visit questionable sites. It's the scripts that the site owner has no control over that are the real issue.
I think Dragon+Sandboxie is a fine replacement for Firefox+NoScript. It's even a fine replacement for Firefox+AdBlock Plus. I'm completely comfortable with Dragon+Sandboxie, although AdBlock Plus for Chrome isn't as functional yet as ABP for Firefox.