Personally I like MSE. My only problem with it is that it's not very configurable.
I believe that Comodo Antivirus is finally going to be tested in the next round of AV-Comparatives. I'm also waiting to see the results of this test as I can't recommend that anyone use Comodo Antivirus until I see how it stacks up against the competition.
I know it's not bad, but I don't know how good it is.
Also, don't forget that if you configure Comodo Firewall correctly, and answer the alerts wisely, you can't get infected anyway. The worst that can happen is you have malicious files on your system that can't do anything malicious.