What are the most secure settings without enabling HIPS?
Enable “Proactive Security Configuration” and then go to HIPS setting and disable the HIPS.
This is what I use :-TU Very strong configuration!
You can also try Chiron’s recommendations: http://www.techsupportalert.com/content/how-install-comodo-firewall.htm .
Sandbox settings on default?
Set proactive and disable HIPS…leave all settings as defaul proactive settings. Ok :-TU