I talked to Umesh (Head of the AV Labs).
CIS 3.10 is now out. Comodo have now started generating very powerful generic signatures, which catch many many other malware (thousands).
You can tell these signatures look different from before, Because each signature now has Numbers or letters after it (Example: Before in Virus Section it was just
Virus.Win32.Virut being added (Only added for one variant of Virut) Now you all see this...

(DB 1539)
Which represents Generic Signatures. You cannot differentiate however between Generic Signatures and Normal Signatures, But the AV Labs are generating as much Generic Signatures as possible now, Next week the database size will start going down, Because Comodo won't need so many signatures being added now and the format has obviously changed to suite this, and create a higher detection.

Cheers,
Josh