I can see how hotkeys can be potential a potential liability. Use of "safe conputing" and/or something like Prevx should bring the likelyhood of a trojan being present way down. Hotkeys could then be an acceptable risk.
On the other hand, games and other programs that take over at a low level often prevent alt-tabbing back to the desktop to see/respond to a CPF popup. An alt-tab sometimes will bring the popup to the front, indicated by a different cursor in the lower right. With ZoneAlarms's hot keys I could respond to the popup. I can't with CPF.
On the other hand ( how many hands is that

) With CPF I often get popups for other programs that I've allowed many times before. Blindly responding to an unknown popup could be a problem too.
How about an option to make hotkeys available or available only when certain programs are running?