I don't know much about Panda AV, but D+ should not interfere with any software, as long as the appropriate rules are set up.
If you are unsure about setting up rules, you can always use the training mode if you are sure your system is clean. Run Panda AV, do a scan etc. When done, revert to the previous mode. The necessary rules will be created. You can always review, modify or delete any rules you believe is too loose or not wanted.
Hope this helps.