Many virus hunters that doesn't use CIS uses CIMA as one of the online tools available to "research" malware itself.
Because of this COMODO can use this community-powered tool to improve your AV detection rates and sent all samples submitted from CIMA to AV Lab (as a malwaresubmit[at]avlab.comodo.com e-mail...).
I currently sent all samples that I discovered to CIMA and VirusTotal only, no more upload threats on this forum.
Every sample goes to the lab (either by email, CIMA, etc.)
CIMA is great because it allows people to analyze their malware and also feeds the malware to COMODO's AV labs so suspicious files will be manually analyzed for anything and a sig will be created, so i guess this is the fastest way.