Hi, lucid717
Can you tell me, please what version of Comodo Secure Email (CSE) do you have installed? (Run SecureEmail Configuration and click About button)?
Every day I keep getting a pop up that there's an update for CSE, and every time I try to install it, no matter if I try to save the file or run it, nothing happens... then the next day it says the update is available again. It's been happening for a few days now. The file is 4.32 MB.
CSE is checking if version on server if newer than installed and prompt to user about new version found.
So, if you still have old version (1.1.0.7 for example) it would ask you every day until installation of newer version.
You downloaded this new version and tried to run it and Setup Wizard wasn't shown?
Actually - It seems to me that You have a problem with newer version.
Can you try to download it again - to be sure that it was downloaded successfully?
Can you tell me, please, Your PC configuration to analize your issue:
1) Windows OS installed
2) Service Pack installed if any for this OS
3) Any Antivirus software installed
Thanks for using Comodo

Regards, Eugene