Choose any app in computer security policy -> edit -> protection settings.
Set any switch (e. g. process terminations) to "yes". Add any exceptions by clicking "modify" (e. g. windows system applications group).
Apply everywhere. Exceptions are not remembered and not applied.
I can verify that this also happens for me with v220.127.116.115 on x32 XP SP2. This was not a problem in v18.104.22.1686. I'll be sticking with v22.214.171.1246 until this is fixed.