Well, the only way I could disable self-defense is to have someone remotely go into my computer and do it for me.
I will let you know the steps. There are easy ways to disable it manually. All you need to do is to manually rename c:\windows\system32\drivers\cmdguard.sys file to something else and then restart your PC. This will disable CIS and it will let you know to do this manually.
After restarting, you need to open cfp.exe or CIS GUI,
1 - Go to Defense+->Computer Security Policy->Defense+ Rules
2 - Click entry named COMODO Internet Security and click on Edit button
3 - In the opened window, click on Customize button
4 - Click on Protection Settings tab, and you will see protection items grid
5 - In this grid, you can do 2 things: Disable interprocess memory access protection by simply clicking on the checbox in Inactive column or
6 - You can click on Modify button in the exceptions column where you can add all of the files related to your support software. You need to click on Add->Browse button and choose the installation path of the support sofware and add them to exceptions.(nvda.exe is the file that is being blocked from accessing CIS memory but you can add all the files)
7 - Restore c:\windows\system32\drivers\cmdguard.sys file back and restart.
After these steps, eveerything should be fine.
We are currently checking what else we can do to help visually impaired users without having them following these steps.
Sorry for the inconvenience.