I guess you are talking about the manual scanning, if it is that then I don´t. Because it will slowdown your scan, besides every unknown file will be submitted to the cloud. Go to "D+", "execution control settings" "automatically scan unrecognized files in the cloud". It is on by default.
BTW i am not a experienced user

. I have been using Comodo anti-virus for 5 months, since V5
Regards