You don't need anyone to tell you that this is indeed a fatal vulnerability.

Imagine if a malware the likes of Conficker showed up and targeted every PC that's "protected" by CIS and/or any other brand of IS whose product also has this weakness. Factor in that most windows users are always logged in with admin privileges and their novice selves likely allow everything if a HIPS is present...
Any fatal vulnerability, Unlocker is an application "Safe" for this motive D+ in Safe Mode learns all the activities without stopping nothing.
It would spell doomsday for Comodo and/or the other vendor(s). Trust, reputation and (consequently) income would do like a sky-diver who forgot his parachute...
Or imagine that you allow some "safe/trusted system-looking" program to run... Defense+ alerts you, yes, but the alert doesn't tell you that the program is targeting CIS' (or non-CIS critical) components. Whatever's done is done in the background and you go about your merry way... come back... turn off the PC and catch a sleep.
Then the next morning you turn on your PC and realize either immediately... or too late (after, let's say, the program's trojan horse strikes/has struck) that CIS. No. Longer. Works. Then what?

A program "Safe" it doesn't have as target the elimination of cmdagent.exe.
Putting D+ in Paranoid Mode we will have more popups that they point out us what it happens, I put the last two, those that stop the elimination of cmdagent.exe (I attach screenshot).
screen 1 Allow (..Block is better

)
screen 2 Si (yes)
screen 3 Block
Restart..cmdagent isn't deleted (also accept driver installation).
Sorry for my English, thanks.
Regards.