Disabling Javascript (well, scripts in general) is what makes NoScript so fantastic. With it, I'm not sure that Spyware Blaster and similar software is required.
I also think one should disable cookies, and just allow some important ones (based on a personal white list).
/LA
Well why not i mean there still can be some stuff. For a set and forget spyware blaster should be used no matter what you have disabled
