I wouldn't ditch AV If I were you, You need it.
I agree with this statement. I strongly prefer to not allow malware to execute at all, and that's why resident anti-malware scanners are a good idea IMHO, even if you are using Comodo Firewall 3. However, if the resident anti-malware scanner(s) don't catch the malware, then Comodo Firewall 3 is there to try to prevent/limit damage. At the very least, Comodo Firewall 3 could perhaps give an indication that malware was indeed run, which might prompt me to restore a recent system backup to make sure that no crud/damage remains.