Does excluding the pagefile from the AV on access scan bring any solace here? This trick helps older system with 512 or less MB of RAM.
I think the amount of memory is the key here. When I access my XP installation with 1 GB of RAM, after sometimes 5 or more days, it takes a while to process but it does not bring the system to its knees. It surely influences but I can start programs and even install applications.
I started experiencing this issue with the release of 3.12. I never used to have any problems before. I don't need to wait a week though. Just having the system off overnight is long enough. Then a few minutes after startup when CIS starts its update, I can't use my system for 5 or so minutes.
My system has 2GB of RAM, so I don't think it's a memory issue. I have excluded the pagefile with no success.
My hope is that Comodo sees this behavior as a priority issue. It's annoying enough that I'm actually considering another security solution.